Thermo Fisher Scientific IL-29 Recombinant Rabbit Monoclonal Antibody (001)

Applications

Western Blot (WB)

• Tested dilution: Not specified
• View 1 publication

ELISA

• Tested dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Human IL-29.

Target Information

IFN-lambdas constitute a novel family of interferons that mediate the induction of antiviral protection in a wide variety of cells. There are three members in this family—lambda1, lambda2, and lambda3—also known as IL-29, IL-28A, and IL-28B, respectively.

Similar to type I IFNs, IFN-lambdas activate intracellular signaling to promote gene expression. They mediate antiviral protection through a class II cytokine receptor complex composed of two essential receptor proteins: CRF2-12/IFN-lambdaR1 (unique to IFN-lambdas) and CFR2-4/IL-10R2 (shared with IL-10, IL-22, and IL-26 receptors).

IL-28 and IL-29 have been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. Dendritic cells differentiated in response to IFN-lambdas express high levels of class I and II MHC gene products but low levels of costimulatory molecules. These cells can specifically induce IL-2-dependent proliferation of CD4⁺CD25⁺FOXP3⁺ T cells with contact-dependent suppressive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.