Thermo Fisher Scientific IL-29 Recombinant Rabbit Monoclonal Antibody (001)
Human IL-29을 특이적으로 인식하는 recombinant rabbit monoclonal antibody. Western blot 및 ELISA에 적합하며, 높은 특이성과 재현성을 제공. 보존제가 없는 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested dilution: Not specified
- View 1 publication
ELISA
- Tested dilution: 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 001 |
| Immunogen | Recombinant Human IL-29 Protein (Met1–Thr200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786377 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
This antibody has specificity for Human IL-29.
Target Information
IFN-lambdas constitute a novel family of interferons that mediate the induction of antiviral protection in a wide variety of cells. There are three members in this family—lambda1, lambda2, and lambda3—also known as IL-29, IL-28A, and IL-28B, respectively.
Similar to type I IFNs, IFN-lambdas activate intracellular signaling to promote gene expression. They mediate antiviral protection through a class II cytokine receptor complex composed of two essential receptor proteins: CRF2-12/IFN-lambdaR1 (unique to IFN-lambdas) and CFR2-4/IL-10R2 (shared with IL-10, IL-22, and IL-26 receptors).
IL-28 and IL-29 have been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. Dendritic cells differentiated in response to IFN-lambdas express high levels of class I and II MHC gene products but low levels of costimulatory molecules. These cells can specifically induce IL-2-dependent proliferation of CD4⁺CD25⁺FOXP3⁺ T cells with contact-dependent suppressive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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