Thermo Fisher Scientific PGP9.5 Recombinant Rabbit Monoclonal Antibody (JF93-08)
Recombinant rabbit monoclonal antibody targeting PGP9.5 (UCH-L1), clone JF93-08. Validated for WB, IHC, ICC/IF, and IP. High specificity and lot-to-lot consistency with HEK293 expression system. Suitable for neuronal marker and neurodegenerative diseas...
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Thermo Fisher Scientific PGP9.5 Recombinant Rabbit Monoclonal Antibody (JF93-08)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 1:50–1:100 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JF93-08 |
| Immunogen | Synthetic peptide within Human PGP9.5 aa 50–90 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809828 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
PGP9.5 (Protein Gene Product 9.5, UCH-L1, PARK5) is a neuron-specific protein distinct from neuron-specific enolase, with a molecular weight of 27 kDa. It belongs to the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12).
PGP9.5 exhibits ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate monomers. It is expressed in neurons and nerve fibers throughout the central and peripheral nervous system, neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells.
Overexpression is associated with non-small cell lung cancer, while decreased expression is linked to Huntington and Alzheimer diseases. PGP9.5 serves as a useful neuronal marker and is valuable in neurodegenerative disorder studies such as Parkinson disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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