Thermo Fisher Scientific GLI3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
• Based on 100% sequence identity, this antibody is predicted to react with Mouse and Chimpanzee.

Target Information

This gene encodes a protein belonging to the C2H2-type zinc finger proteins subclass of the Gli family. These proteins act as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The encoded protein localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It also plays a role during embryogenesis.
Mutations in this gene are associated with several disorders, including:

• Greig cephalopolysyndactyly syndrome
• Pallister-Hall syndrome
• Preaxial polydactyly type IV
• Postaxial polydactyly types A1 and B

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.