Thermo Fisher Scientific GLI3 Polyclonal Antibody
Rabbit polyclonal antibody against GLI3 protein. Suitable for IHC with citrate buffer pH 6.0 for FFPE tissues. Predicted to react with mouse and chimpanzee. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 875–925 of GLI3 (UniProt ID: P10071-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Chimpanzee.
Target Information
This gene encodes a protein belonging to the C2H2-type zinc finger proteins subclass of the Gli family. These proteins function as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The encoded protein localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also implicated in embryogenesis. Mutations in this gene have been associated with several diseases, including:
- Greig cephalopolysyndactyly syndrome
- Pallister-Hall syndrome
- Preaxial polydactyly type IV
- Postaxial polydactyly types A1 and B
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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