Thermo Fisher Scientific ATP6V1F Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: U87-MG
• Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (82%), Xenopus laevis (83%), Chimpanzee (100%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

ATP6V1F encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme mediating acidification of eukaryotic intracellular organelles.
V-ATPase-dependent organelle acidification is essential for processes such as:

• Protein sorting
• Zymogen activation
• Receptor-mediated endocytosis
• Synaptic vesicle proton gradient generation

V-ATPase consists of:

• V1 domain (cytosolic): three A, three B, two G, plus C, D, E, F, and H subunits — contains ATP catalytic site
• V0 domain (transmembrane): subunits a, c, c′, c″, and d

Additional isoforms of many V1 and V0 subunits are encoded by multiple genes or alternatively spliced transcripts.
ATP6V1F encodes the V1 domain F subunit protein.

⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

제품 이미지

(해당 항원 구조 이미지: PA5-27516_ATP6V1F_Q16864-1_Rabbit.svg 및 PA5-27516_ATP6V1F_Q16864-1_Rabbit_PDP.jpeg)