Thermo Fisher Scientific DERL1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

5-10 µg/mL

-

Immunocytochemistry (ICC/IF)

1:2,000

-

Product Specifications

Species Reactivity

Dog, Hamster, Human, Mouse

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to the C-terminal residues 200-251 of human Derlin-1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DERL1,uniProtId:Q9BUN8-1,ncbiNodeId:9606,antigenRange:200-251,antigenLength:251,antigenImageFileName:PA1-16598_DERL1_Q9BUN8-1_Rabbit.svg,antigenImageFileNamePDP:PA1-16598_DERL1_Q9BUN8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

tris citrate/phosphate, pH 7-8

Contains

0.1% sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Wet ice

RRID

AB_2230554

Product Specific Information

This antibody is predicted to react with xenopus, bovine, chicken, rat, zebrafish, and mouse based on 100% sequence homology.

Suggested positive control: antigen standard for DERL1 (transient overexpression lysate), KRM (canine microsome) lysates.

Target Information

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.