Thermo Fisher Scientific Cathelicidin Polyclonal Antibody
Human Cathelicidin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 비결합형 액상 형태. 인체 방어 관련 연구용으로 적합하며, 인체 spleen lysate를 양성 대조군으로 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid synthetic peptide near the center of the human Cathelicidin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156015 |
Product Specific Information
- Suggested positive control: human spleen tissue lysate
- PA5-20513 can be used with blocking peptide PEP-0633
- The immunogen is located within amino acids 50–100 of Cathelicidin
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis, and neutrophils.
Cathelicidins are a family of antimicrobial peptides characterized by conserved pro-peptide sequences identified in epithelial tissues and some myeloid cells of humans and animals.
LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells.
These molecules are essential for defense against invasive bacterial infection in skin.
Besides direct antimicrobial function, Cathelicidins play roles in innate and adaptive immunity, including endotoxin neutralization, angiogenesis, wound healing, neutrophil chemotaxis, and mast cell recruitment.
Cathelicidin antimicrobial peptides are prototypes of innovative drugs that may treat infection and/or modulate immune responses.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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