Thermo Fisher Scientific TIMD4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL
• Suggested Positive Control: Jurkat cell lysate
• Blocking Peptide: PEP-0365

Product Specifications

Product Specific Information

A suggested positive control is Jurkat cell lysate.
PA5-20247 can be used with blocking peptide PEP-0365.

Target Information

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors involved in the regulation of T helper (Th)1 and Th2 cell-mediated immunity. TIM-4, preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and, due to its connection to TIM-1-triggered Th2 responsiveness, may be considered a candidate disease/predisposition gene for asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.