Thermo Fisher Scientific Human Nhe-1 Synthetic Peptide
인간 Nhe-1 단백질의 중심부 17개 아미노산 서열로 구성된 합성 펩타이드. 항체 PA5-20446의 차단 펩타이드로 사용 가능. 세포 내 pH 조절 연구 및 Nhe-1 관련 기능 연구에 적합. 액상 형태, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the center of human Nhe-1.
PEP-0563 can be used as a blocking peptide with polyclonal antibody PA5-20446.
Target Information
The Na⁺/H⁺ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by various signals including growth factors, mitogens, neurotransmitters, and tumor promoters.
Nhe-1 acts as an anchor for actin filaments to maintain the integrity of the cortical cytoskeleton through structural links with actin-binding proteins ezrin, radixin, and moesin (ERM proteins).
A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton independent of its ion exchange function. It is also thought to play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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