Thermo Fisher Scientific Human Grik1 Synthetic Peptide

Thermo Fisher Scientific Human Grik1 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the carboxy terminus of human Grik1.
PEP-0564 can be used as a blocking peptide with polyclonal antibody PA5-20447.

Target Information

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in various normal neurophysiologic processes.
Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.
Grik1 is expressed in GABAergic interneurons of the hippocampus and is thought to participate in forming various subtypes of kainate receptors with Grik2 and KA2.
Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological, and neurodegenerative diseases.
Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter ion flow properties.

Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.