Thermo Fisher Scientific Phospho-BCR (Tyr276) Polyclonal Antibody
Phospho-BCR (Tyr276) 폴리클로날 항체로, 인간 및 영장류 시료에서 인산화된 BCR 단백질 검출에 적합합니다. Western blot에 최적화되어 있으며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.01–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (265 HKLGGGQYGEV(Y)EGV 279) of Phospho-Bcr/Abl pTyr276 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540853 |
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein encoded by sequences from both BCR and ABL, the gene at the chromosome 9 breakpoint.
Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product remains unclear. The protein exhibits serine/threonine kinase activity and functions as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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