Thermo Fisher Scientific Phospho-Catenin-b (Ser675) Polyclonal Antibody
Phospho-Catenin-b (Ser675)에 특이적인 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트에 반응합니다. Western blot 및 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포막 및 세포질에서 베타-카테닌 발현 연구에 유용합니다.
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Thermo Fisher Scientific Phospho-Catenin-b (Ser675) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to epitope -KRLSVEL- with phosphorylation site Ser675 of human beta-catenin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: HeLa cell lysate
- Cellular location: Cell membrane, cytoplasm
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin, linking adhesion complexes to the actin cytoskeleton. Beta-catenin also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, and participates in signaling pathways such as Wnt/Wingless.
It is expressed in hair follicle cells and epithelial tissues. Aberrant beta-catenin activity is implicated in various cancers, including colorectal, ovarian, and breast tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, regulating genes like cyclin D and c-myc that drive cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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