Thermo Fisher Scientific Phospho-Cyclin B1 (Ser147) Polyclonal Antibody
Cyclin B1의 Ser147 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 사람, 마우스, 랫트 시료에 반응. 세포주기 G2/M 전이 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CCNB1 (Accession P14635), corresponding to amino acid residues around phosphorylated Ser147. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816269 |
Product Specific Information
This antibody detects endogenous levels of Cyclin B1 only when phosphorylated at Serine 147.
Target Information
Cyclins bind to and regulate the activity of Cyclin-dependent protein kinases (CDKs). Cyclin B1 (CCNB1) is a regulatory protein essential for the control of the cell cycle at the G2/M transition. It forms a complex with p34 (cdc2) to create the maturation-promoting factor (MPF). Two alternative transcripts exist: one constitutively expressed and another cell cycle–regulated, expressed predominantly during G2/M phase. Cyclin B1 accumulates during G2 phase and is degraded at the end of mitosis by APC-dependent mechanisms. Overexpression of Cyclin B1 has been observed in several cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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