Thermo Fisher Scientific SHOX Polyclonal Antibody
SHOX 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도(>95%)로 정제되었습니다. 29 kDa의 내인성 단백질을 검출하며, 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA537220
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human SHOX |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553969 |
Product Specific Information
- This antibody detects endogenous protein at a molecular weight of 29 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
Homeodomain proteins (HP) are transcriptional regulators that coordinate the expression of genes involved in development, differentiation, and cellular transformation. HPs have a conserved domain of 60 amino acid residues that recognize and bind sites in regulatory regions of target genes.
SHOX, a member of the bicoid subfamily of the paired homeobox family, controls fundamental aspects of growth and development and undergoes alternative splicing resulting in two isoforms, SHOXA and SHOXB.
- SHOXA: Expressed in skeletal muscle, placenta, pancreas, heart, and bone marrow fibroblasts; lower expression in kidney and lung.
- SHOXB: Highly expressed in osteogenic cells; not expressed in brain, kidney, liver, or lung.
Defects in the SHOX gene cause Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LMD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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