Thermo Fisher Scientific COMT Polyclonal Antibody
COMT 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot 및 IHC(P)에서 검증됨. 인간 시료에 반응하며, 비결합형 액상 형태로 제공. COMT 관련 신경전달물질 대사 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.03–0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (QDIIPQLKKKYDVD) corresponding to the internal amino acids of COMT (aa 170–184) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980251 |
Product Specific Information
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including dopamine, epinephrine, and norepinephrine.
This O-methylation is a major pathway for catecholamine degradation.
COMT also plays a key role in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson’s disease.
It exists in two forms: a soluble form (S-COMT) and a membrane-bound form (MB-COMT), differing at their N-termini.
Multiple transcript variants are generated through alternative translation initiation sites and promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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