Thermo Fisher Scientific Phospho-ROS1 (Tyr2274) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the γ phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.

With more than 500 gene products, the protein kinase family is one of the largest in eukaryotes. It includes 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group primarily regulates cell-cell interactions such as differentiation, adhesion, motility, and death. Approximately 90 TK genes have been sequenced, including 58 receptor protein TKs (e.g., EGFR, EPH, FGFR, PDGFR, TRK, VEGFR) and 32 cytosolic TKs (e.g., ABL, FAK, JAK, SRC).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.