Thermo Fisher Scientific ALDH3A1 Recombinant Rabbit Monoclonal Antibody (316)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, followed by screening to select the best clones for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Human ALDH3A1.

Target Information

Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. It is highly expressed in the stomach and more strongly in the cornea, representing 5–50% of the water-soluble protein fraction in mammalian corneas. Aldh3A1 is thought to protect the cornea from UV-induced oxidative stress by detoxifying reactive aldehydes and directly absorbing UV energy. Although Aldh3A1- mice show no corneal differences compared to wild-type, mice lacking both Aldh3A1 and Aldh1A1 exhibit increased cataract formation following UVB exposure, suggesting Aldh1A1 may compensate for the loss of Aldh3A1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.