Thermo Fisher Scientific Androgen Receptor Monoclonal Antibody (1A9D12)
인간 Androgen Receptor를 인식하는 Mouse monoclonal 항체로, Western blot 및 ELISA에 적합합니다. 정제된 AR 단백질 조각(aa689-919)을 면역원으로 사용하였으며, 비결합(Unconjugated) 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A9D12 |
| Immunogen | Purified recombinant fragment of AR (aa689–919) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10985605 |
Product Specific Information
MA5-15455 targets Androgen Receptor (AR) in indirect ELISA and Western blot applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of AR (amino acids 689–919) expressed in E. coli.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors.
It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT), dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR signaling plays a key role in:
- Development and function of male reproductive organs (prostate, epididymis)
- Regulation in nonreproductive tissues (muscle, hair follicles, brain)
- Phosphorylation and MAP kinase pathway regulation
Abnormalities in AR signaling are associated with:
- Prostate cancer
- Kennedy’s disease
- Male infertility
- Complete androgen insensitivity syndrome (CAIS)
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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