Thermo Fisher Scientific Argonaute 3 Polyclonal Antibody
인간 Argonaute 3 단백질을 인식하는 Rabbit Polyclonal 항체. 면역세포염색(ICC/IF)에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS와 글리세롤 완충액에 보관되며, RNA 매개 유전자 침묵 연구에 유용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Argonaute 3 protein. Recombinant protein control fragment (Product #RP-108047) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664808 |
Product Specific Information
- Immunogen sequence: MEIGSAGPAGA QPLLMVPRRP GYGTMG
- Sequence identity: Mouse 89%, Rat 93%
Target Information
AGO3 (Argonaute-3) is required for RNA-mediated gene silencing (RNAi).
It binds to short RNAs such as microRNAs (miRNAs) and represses translation of complementary mRNAs.
AGO3 is proposed to stabilize small RNA derivatives (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells, and to mediate riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting an mRNA decapping complex involving EDC4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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