Thermo Fisher Scientific TNF alpha Recombinant Rabbit Monoclonal Antibody (2Y4O4)
Recombinant rabbit monoclonal antibody targeting human TNF alpha (clone 2Y4O4). Suitable for IHC and ELISA applications. High purity via affinity chromatography, supplied as liquid in PBS buffer with BSA and glycerol. For research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2Y4O4 |
| Immunogen | Recombinant fusion protein containing amino acids 77–233 of human TNF alpha (NP_000585.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.31 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093013 |
Product Specific Information
Immunogen sequence:
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL
Target Information
TNF alpha is a multifunctional proinflammatory cytokine belonging to the tumor necrosis factor (TNF) superfamily. It is mainly secreted by macrophages and binds to its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha regulates immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
It exists as multimers of two, three, or five noncovalently linked units but shows a single 17 kDa band under non-reducing SDS-PAGE conditions. Knockout studies in mice suggest TNF alpha has neuroprotective functions and induces tumor necrosis in tumor-bearing mice. It plays a key role in immune responses to bacterial, viral, parasitic, and certain fungal infections, and contributes to tumor cell cytolysis or cytostasis synergistically with interferon-gamma. TNF alpha is implicated in autoimmune diseases, insulin resistance, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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