Thermo Fisher Scientific TRPM4 Monoclonal Antibody (OTI10H5), TrueMAB
TRPM4 단백질을 인식하는 마우스 단클론 항체로, Western blot과 IHC(P)에서 사용 가능. 인간 및 개 시료에 반응하며, Affinity chromatography로 정제됨. PBS/BSA/glycerol buffer에 보관되며 -20°C에서 안정적. 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10H5 |
| Immunogen | Full length human recombinant protein of human TRPM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. While it is activated by an increase in intracellular Ca²⁺, it is impermeable to it. Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization. Plays a central role in cardiomyocytes, neurons from the entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, and cochlear hair cells. Participates in T-cell activation by modulating Ca²⁺ oscillations after T lymphocyte activation, required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or irregular electrical activity under Ca²⁺ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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