Thermo Fisher Scientific ALDH3A1 Monoclonal Antibody (OTI1C6), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Aldh3A1 belongs to the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide range of aldehydes.
It is highly expressed in the stomach and cornea, where it can represent up to 50% of the water-soluble protein fraction.
Aldh3A1 protects the cornea from UV-induced oxidative stress through detoxification of reactive aldehydes and absorption of UV energy.
Although Aldh3A1-deficient mice show no corneal abnormalities, double knockout mice (Aldh3A1 and Aldh1A1) exhibit increased cataract formation after UVB exposure, suggesting compensatory roles between these enzymes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.