Thermo Fisher Scientific GRIP1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Associated proteins known as coactivators and corepressors enhance or repress transcription activity of the nuclear receptor with which they associate.
Glucocorticoid receptor interacting protein-1 (GRIP1), also known as Transcription Intermediary Factor 2 (TIF2), is a member of a family of transcriptional coactivator proteins that includes steroid receptor coactivator-1 (SRC-1) and Amplified in breast cancer-1 (AIB-1).
GRIP1 has been shown to interact with and stimulate transcriptional activity of retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator-activated receptors. GRIP1 also contains several copies of the conserved LXXLL/LLXXL motif, which is critical to receptor-coactivator interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.