Thermo Fisher Scientific WIBG Monoclonal Antibody (OTI1E10), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

WIBG is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs. It acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents translation-independent disassembly of the EJC from spliced mRNAs. WIBG interferes with nonsense-mediated mRNA decay (NMD) and enhances translation of spliced mRNAs, likely by antagonizing EJC functions. It may bind RNA, though the relevance of RNA-binding remains unclear in vivo.
[Source: UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.