Thermo Fisher Scientific CREB1 Monoclonal Antibody (5F2)
CREB1 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단일클론 항체(5F2). Western blot, IHC, ELISA, PLA 등 다양한 응용에 적합. 인간 시료 반응성, 비결합형 액상 형태. 친화 크로마토그래피로 정제, 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL |
| ELISA | 1 ng/mL |
| in situ PLA (PLA) | 1:1200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5F2 |
| Immunogen | CREB1 (NP_004370, 1 a.a. – approx. 95 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESE
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals such as neurotransmitters, hormones, membrane depolarization, and growth or neurotrophic factors. Activation of CREB depends on the phosphorylation of serine 133, mediated by p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1. While CREB can bind DNA regardless of phosphorylation, only the phosphorylated form acts as a transcription factor. CREB binding protein (CBP) interacts with CREB at serine 133 and serves as a transcriptional coactivator. CREB plays roles in circadian rhythm synchronization, adipocyte differentiation, and learning and memory. The human CREB gene is located on chromosome 2q. Dysregulation of CREB is linked to diseases such as Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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