Thermo Fisher Scientific PF4 Recombinant Rabbit Monoclonal Antibody (ARC2076)
PF4 단백질을 표적하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. 인간, 생쥐, 랫트 반응성 보유. HEK293 세포 발현, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2076 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–101 of human CXCL4/PF4 (UniProt ID: P02776) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898007 |
Product Specific Information
- Positive Samples: Human plasma, Mouse spleen
- Immunogen sequence:
MSSAAGFCAS RPGLLFLGLL LLPLVVAFAS AEAEEDGDLQ CLCVKTTSQV RPRHITSLEV IKAGPHCPTA QLIATLKNGR KICLDLQAPL YKKIIKKLLE S
Target Information
Platelet factor 4 (PF4) is a 70-amino acid protein released from the alpha-granules of activated platelets. It binds with high affinity to heparin and plays a key role in neutralizing heparin-like molecules on endothelial surfaces, thus inhibiting local antithrombin III activity and promoting coagulation. PF4 also acts as a chemoattractant for neutrophils and fibroblasts, contributing to inflammation and wound repair (Eisman et al., 1990).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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