Thermo Fisher Scientific Phospho-p70 S6 Kinase (Ser427) Polyclonal Antibody
인간 p70 S6 Kinase의 Ser427 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합합니다. 세포 성장 및 단백질 합성 조절 연구에 활용되며, 고순도 액상 형태로 −20°C 보관 가능합니다.
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Thermo Fisher Scientific Phospho-p70 S6 Kinase (Ser427) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human p70 S6 Kinase around the phosphorylation site of Ser427 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817307 |
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylate several residues of the S6 ribosomal protein.
p70 S6 kinase is predominantly localized in the cytoplasm and plays essential roles in growth factor-regulated cell proliferation, pathways involving cell motility (such as metastasis), immune response, and tissue repair.
It acts downstream of phosphoinositide (PI) 3-kinase, with the S6 ribosomal protein as its main physiological target, contributing to upregulated protein synthesis and cell proliferation.
Amplification and overexpression of p70 S6 kinase have been observed in certain breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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