Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI4B10), TrueMAB
MDM4 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 Immunocytochemistry에 사용 가능. Human 시료에 반응하며, Affinity chromatography로 정제된 액상 형태. PBS, BSA, glycerol 함유하며 -20°C에서 보관. 연구용 전용 시약.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI4B10), TrueMAB
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B10 |
| Immunogen | Full length human recombinant protein of human MDM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2.
The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas.
ARF interacts with MDMX to sequester MDMX within the nucleolus, resulting in an increase in p53 transactivation.
Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation.
Like MDM2, MDMX also binds p73 and stabilizes the level of p73, increasing the half-life of p73 by binding to MDM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.