Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI1E8), TrueMAB
인간 MDM4 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, WB 및 ICC/IF에 적합. TrueMAB 형식으로 높은 특이성과 재현성을 제공. HEK293T 세포에서 생산된 전체 길이 MDM4 단백질로 면역화됨. 연구용으로만 사용 가능.
- 카탈로그번호
- TA505732
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E8 |
| Immunogen | Full length human recombinant protein of human MDM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX (also known as MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 through distinct associations with MDM2. The MDMX gene is often amplified in malignant gliomas. ARF interacts with MDMX to sequester it within the nucleolus, increasing p53 transactivation. Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. MDMX also binds and stabilizes p73, increasing its half-life in contrast to p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: TA505732_MDMX_O15151-1_House_mouse.svg, TA505732_MDMX_O15151-1_House_mouse_PDP.jpeg)
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