Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI4D2), TrueMAB
MDM4 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot과 Immunocytochemistry에 사용 가능. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 보관. p53 안정성 조절 연구에 적합한 연구용 항체.
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Applications
- Western Blot (WB): 1:4,000
- Immunocytochemistry (ICC/IF): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D2 |
| Immunogen | Full length human recombinant protein of human MDM4 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX (also designated MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2.
The gene encoding MDMX is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus, increasing p53 transactivation.
Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes its level, increasing the half-life of p73.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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