Thermo Fisher Scientific XRCC5 (Ku86/Ku80) (Thyroid-Lupus Autoantigen) Monoclonal Antibody (XRCC5/7315)
Western blot 및 IHC에 적합한 XRCC5(Ku80) 단클론 항체. 인간 시료 반응성, Mouse IgG1, kappa 아이소타입. Protein A/G 정제, 200 µg/mL 농도. PBS(pH 7.4) + 0.05% BSA 보존, 4°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | XRCC5/7315 |
| Immunogen | Recombinant fragment (around aa300–500) of human XRCC5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The XRCC5 gene encodes the 80-kDa subunit of the Ku heterodimer protein, also known as ATP-dependent DNA helicase II or DNA repair protein XRCC5. Ku acts as the DNA-binding component of the DNA-dependent protein kinase and functions with the DNA ligase IV–XRCC4 complex in repairing DNA double-strand breaks via non-homologous end joining and completing V(D)J recombination. This gene complements the Chinese hamster xrs-6 mutant defective in DNA repair and recombination. A rare microsatellite polymorphism in XRCC5 has been associated with cancer susceptibility and radiosensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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