Thermo Fisher Scientific XRCC5 (Ku86/Ku80) (Thyroid-Lupus Autoantigen) Monoclonal Antibody (XRCC5/7315)
인간 XRCC5(Ku86/Ku80) 단백질을 인식하는 mouse monoclonal antibody입니다. Western blot 및 IHC에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. DNA 복구 관련 Ku 단백질 연구용으로 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | XRCC5/7315 |
| Immunogen | Recombinant fragment (around aa300–500) of human XRCC5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein, also known as ATP-dependent DNA helicase II or DNA repair protein XRCC5.
Ku functions as the DNA-binding component of the DNA-dependent protein kinase and works together with the DNA ligase IV–XRCC4 complex in the repair of DNA double-strand breaks via non-homologous end joining and in V(D)J recombination.
This gene complements Chinese hamster xrs-6 mutants defective in DNA double-strand break repair.
A rare microsatellite polymorphism in this gene is associated with cancer and varying radiosensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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