Thermo Fisher Scientific PDE8A Polyclonal Antibody

Applications

Tested Applications and Dilution

Product Specifications

Product Specific Information

Predicted Reactivity: Mouse (80%), Rhesus Monkey (99%), Bovine (87%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides act as second messengers in multiple physiological processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families, distinguishable by structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Their diversity makes PDEs promising targets for pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.