Thermo Fisher Scientific PDE8A Polyclonal Antibody
Rabbit polyclonal antibody against human PDE8A for ICC/IF applications. Recognizes recombinant protein sequence within human PDE8A. High purity via antigen affinity chromatography. Supplied as liquid, 1 mg/mL in PBS with glycerol. For research use only.
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Applications
Tested Applications and Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human PDE8A (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736333 |
Product Specific Information
Predicted Reactivity: Mouse (80%), Rhesus Monkey (99%), Bovine (87%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides act as second messengers in multiple physiological processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families, distinguishable by structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Their diversity makes PDEs promising targets for pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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