Thermo Fisher Scientific Cortisol Polyclonal Antibody

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Chemical

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Cortisol-21-hemisuccinyl-KLH/BSA/Fetuin mixture.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_930194

Product Specific Information

PA1-85347 detects Cortisol. The following cross-reactivities have been observed: Cortisol-100%, Corticosterone- >90%.

Sheep anti cortisol antibody recognizes the glucocorticoid hormone cortisol, produced in the adrenal cortex and involved in responses to stress. Observed cross reactivities include: Cortisol 100%, Corticosterone >90%.

Target Information

Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.