Thermo Fisher Scientific Cortisol Polyclonal Antibody
코르티솔에 특이적인 다클론 항체로, 엘리사(ELISA)에 사용 가능. 양(IgG) 유래 항체이며, 친화 크로마토그래피로 정제됨. 코르티솔 100%, 코르티코스테론 90% 이상 교차 반응. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품.
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Thermo Fisher Scientific Cortisol Polyclonal Antibody
Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chemical |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Cortisol-21-hemisuccinyl-KLH/BSA/Fetuin mixture |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_930194 |
Product Specific Information
PA1-85347 detects Cortisol. The following cross-reactivities have been observed:
- Cortisol: 100%
- Corticosterone: >90%
Sheep anti-cortisol antibody recognizes the glucocorticoid hormone cortisol, produced in the adrenal cortex and involved in stress responses.
Target Information
Cortisol is the most potent glucocorticoid produced by the human adrenal gland. It is synthesized from cholesterol, and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH), which is regulated by corticotropin releasing factor (CRF).
ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma, most cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin).
Cortisol acts through specific intracellular receptors and affects numerous physiological systems including immune function, glucose counter-regulation, vascular tone, and bone metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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