Thermo Fisher Scientific Phospho-beta Catenin (Ser33, Ser37, Thr41) Polyclonal Antibody
인간, 생쥐, 랫트에서 인산화된 β-Catenin(Ser33/37/Thr41) 검출용 폴리클로날 항체. Western blot 및 ICC/IF에 적합하며 고순도 정제된 액상 형태. 세포 신호전달 및 암 연구에 활용 가능.
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- PA5101044
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTNNB1 (Accession P35222), corresponding to amino acid residues around phosphorylated Ser37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815873 |
Product Specific Information
Antibody detects endogenous levels of beta Catenin only when phosphorylated at Ser33/37/Thr41.
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and signaling. It interacts with E-cadherin and alpha-catenin to anchor the adhesion complex to the actin cytoskeleton.
Beta-catenin also associates with the adenomatous polyposis coli protein and microtubules, participating in Wnt/Wingless signaling pathways.
It plays a role in morphogenesis and is expressed in various hair follicle cells.
Pathologically, beta-catenin is linked to pilomatrixoma, medulloblastoma, colorectal and ovarian cancers, and tumor development.
In the nucleus, it co-activates Lef/Tcf transcription factors, promoting transcription of genes such as cyclin D and c-myc, which drive cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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