Thermo Fisher Scientific TRPC4 Polyclonal Antibody
TRPC4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 사용 가능. 인간 시료 반응성. 합성 펩타이드 기반 면역원 사용. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적 유지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from the 4th cytoplasmic loop of human TRPC4 (TRP4; α, β, γ isoforms) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: TRPC4.
Target Information
TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. It forms a non-selective calcium-permeable cation channel activated by Gq-coupled receptors and tyrosine kinases. TRPC4 is involved in endothelial permeability, vasodilation, neurotransmitter release, and cell proliferation.
Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity. Multiple alternatively spliced transcript variants have been observed.
The TRPC family (TRPC1–7) is closely related to the Drosophila TRP channel. Diseases associated with TRPC4 include Photosensitive Epilepsy.
CaV3.3 encodes a voltage-gated calcium channel subunit involved in neuronal calcium signaling, with slower activation and inactivation compared to other T-type channels. Diseases associated with CACNA1I include Childhood Absence Epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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