Thermo Fisher Scientific ATP6V0D1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: (None listed)

Product Specifications

Product Specific Information

• Recommended positive controls: NT2D1, IMR32, U87-MG
• Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (94%), Xenopus laevis (95%), Chicken (98%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.
V-ATPase–dependent organelle acidification is necessary for intracellular processes such as:

• Protein sorting
• Zymogen activation
• Receptor-mediated endocytosis
• Synaptic vesicle proton gradient generation

V-ATPase is composed of:

• V1 domain (cytosolic): Three A and three B subunits, two G subunits, plus C, D, E, F, and H subunits — contains the ATP catalytic site
• V0 domain (transmembrane): Five different subunits — a, c, c’, c’’, and d

The encoded protein (D subunit) is found ubiquitously. Multiple isoforms of V1 and V0 subunits exist due to alternative splicing or gene duplication.

⚠ WARNING
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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