Thermo Fisher Scientific BMPR1A Monoclonal Antibody (4B7B2)
BMPR1A 단백질을 검출하기 위한 Thermo Fisher Scientific의 단클론 항체로, Human 시료에 반응합니다. Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 적합하며, 단백질 G로 정제된 액상 형태로 제공됩니다. 장기보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | View 1 publication |
| ELISA | 1:10,000 | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B7B2 |
| Immunogen | Purified recombinant fragment of human BMPR1A (amino acids: 179–378) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538508 |
Product Specific Information
MA5-17036 targets BMPR1A in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples.
The immunogen is a purified recombinant fragment of human BMPR1A (amino acids 179–378) expressed in E. coli.
MA5-17036 detects BMPR1A, which has a predicted molecular weight of approximately 60 kDa.
Target Information
BMPR1A is a Type I member of the TGF-beta receptor superfamily of transmembrane serine/threonine kinases that phosphorylate intracellular SMADs in response to bone morphogenic proteins. These receptors are closely related to activin receptors (ACVR1 and ACVR2).
Ligands of these receptors belong to the TGF-beta superfamily. TGF-betas and activins signal through heteromeric complexes with two different types of serine/threonine kinase receptors:
- Type I receptors (~50–55 kDa)
- Type II receptors (~70–80 kDa)
Type II receptors can bind ligands independently but require Type I receptors for signaling, while Type I receptors need Type II receptors for ligand binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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