Thermo Fisher Scientific CaMKIV Monoclonal Antibody (8C5B8)
Human CaMKIV 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC, ICC, Flow Cytometry, ELISA 등 다양한 응용에 적합. Protein G로 정제된 액상 형태이며, 1 mg/mL 농도로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8C5B8 |
| Immunogen | Purified recombinant fragment of human CAMK4 (amino acids 35–292) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538510 |
Product Specific Information
MA5-17038 targets CAMK4 in indirect ELISA, FACS, ICC, IHC, IF, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human CAMK4 (amino acids 35–292) expressed in E. coli.
MA5-17038 detects CAMK4, which has a predicted molecular weight of approximately 58 kDa.
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is involved in transcriptional regulation in lymphocytes, neurons, and male germ cells.
The nuclear localization of CaMKIV supports its role in calcium-dependent gene expression. It is particularly abundant in testis, T-cells, and neurons, and plays a key role in synaptic plasticity and calcium signaling.
In testes, CaMKIV is expressed in germ cells and associated with chromatin, suggesting a role in chromatin remodeling during nuclear condensation in spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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