Thermo Fisher Scientific AMBRA1 Polyclonal Antibody
AMBRA1 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 응용 가능. 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
- 카탈로그번호
- PA5102347
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AMBRA1 (Accession Q9C0C7), corresponding to amino acid residues E1046–A1096 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851754 |
Product Specific Information
Antibody detects endogenous levels of total AMBRA1.
Target Information
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is essential for normal growth control and may be defective in tumor cells. It supports nutrient preservation under starvation and normal cytosolic component turnover.
Beclin-1, a key regulator of autophagosome formation, is regulated by Ambra1. Ambra1 associates with Beclin-1 via a central region identified by yeast two-hybrid assay.
Null mutations in mice lead to embryonic lethality with severe neural tube defects, autophagy impairment, accumulation of ubiquitinated proteins, unbalanced proliferation, and excessive apoptosis.
Down-regulation of Ambra1 through RNA interference decreases rapamycin- and starvation-induced autophagy. Multiple isoforms of Ambra1 exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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