Thermo Fisher Scientific Integrin beta 5 Recombinant Rabbit Monoclonal Antibody (8D2B1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

8D2B1

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 24-490 of human Integrin beta5/ITGB5. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ITGB5 (Integrin beta 5),uniProtId:P18084-1,ncbiNodeId:9606,antigenRange:24-490,antigenLength:799,antigenImageFileName:MA5-55281_ITGB5_Integrin_beta_5_P18084-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55281_ITGB5_Integrin_beta_5_P18084-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.36 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: GLNICTSGSA TSCEECLLIH PKCAWCSKED FGSPRSITSR CDLRANLVKN GCGGEIESPA SSFHVLRSLP LSSKGSGSAG WDVIQMTPQE IAVNLRPGDK TTFQLQVRQV EDYPVDLYYL MDLSLSMKDD LDNIRSLGTK LAEEMRKLTS NFRLGFGSFV DKDISPFSYT APRYQTNPCI GYKLFPNCVP SFGFRHLLPL TDRVDSFNEE VRKQRVSRNR DAPEGGFDAV LQAAVCKEKI GWRKDALHLL VFTTDDVPHI ALDGKLGGLV QPHDGQCHLN EANEYTASNQ MDYPSLALLG EKLAENNINL IFAVTKNHYM LYKNFTALIP GTTVEILDGD SKNIIQLIIN AYNSIRSKVE LSVWDQPEDL NLFFTATCQD GVSYPGQRKC EGLKIGDTAS FEVSLEARSC PSRHTEHVFA LRPVGFRDSL EVGVTYNCTC GCSVGLEPNS ARCNGSGTYV CGLCECS

Target Information

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.