Thermo Fisher Scientific IL-1 alpha Recombinant Rabbit Monoclonal Antibody (9F1T2)

Applications

Product Specifications

Product Specific Information

Immunogen Sequence:
SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS

Target Information

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, shared with IL-1 beta. The IL1A gene is located on chromosome 2q13.

IL-1 alpha plays a key role in innate host defense by inducing other proinflammatory cytokines and initiating acute-phase responses. Its activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which inhibits receptor binding. IL-1 alpha is involved in immune responses, inflammation, and hematopoiesis, and is produced as a proprotein that is processed and released upon cell injury to induce apoptosis. It regulates NF-kappaB and MAPK pathways, stimulates IL6 and COX-2 expression, and enhances nitric oxide production. Elevated IL-1 alpha levels are linked to chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.