Thermo Fisher Scientific TRPV1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-748 detects vanilloid receptor 1 (VR1) from human bladder and skin.
It has been successfully used in immunofluorescence and immunohistochemistry procedures.

• In human glabrous skin, staining is observed in epidermal and dermal cells, free nerve fibers, and Merkel cells.
• In human prostatic urethra, fibrous staining is seen within epithelial cells.

The immunogen is a synthetic peptide corresponding to residues T(7) D L G A A A D P L Q K D T C(21) of human VR1.
The PA1-748 immunizing peptide (Cat. # PEP-202) is available for neutralization and control experiments.

Target Information

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1)
TRPV1 is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a burning pain sensation by activating sensory neurons.
It is a non-selective cation channel related to the TRP family (e.g., TRPC3, TRPC6) and is permeable to calcium, magnesium, sodium, and potassium ions.

Structurally, TRPV1 contains:

• 6 transmembrane domains
• A P-loop membrane domain
• 3 ankyrin repeat domains

TRPV1 is activated by noxious heat and may function as a transducer of painful thermal stimuli. It mediates proton influx and may contribute to intracellular acidosis in nociceptive neurons. Expression is primarily within sensory ganglia neurons.

Diseases associated with TRPV1 include:

• Irritable Bowel Syndrome (IBS)
• Bladder Disease

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.