Thermo Fisher Scientific RARRES2 Monoclonal Antibody (4B12)
RARRES2 단클론 항체(4B12)는 인간 Chemerin(RARRES2) 단백질을 인식하며 Western blot 및 ELISA 분석에 적합합니다. Mouse IgG2a, kappa 형으로 제작되었으며, PBS 버퍼에 보존제가 없는 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Assay-dependent
ELISA
- 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B12 |
| Immunogen | RARRES2 (NP_002880.1, 17–163 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
VGVAELTEAQ RRGLQVALEE FHKHPPVQWA FQETSVESAV DTPFPAGIFV RLEFKLQQTS CRKRDWKKPE CKVRPNGRKR KCLACIKLGS EDKVLGRLVH CPIETQVLRE AEEHQETQCL RVQRAGEDPH SFYFPGQFAF SKALPRS
Target Information
Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs).
Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane bound or secreted.
TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles, and endothelial cells as well as in pancreas, spleen, and intestine.
TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth suppressive effects of retinoids.
TIG2 is a secreted protein mainly expressed in epidermis, hair follicles, and endothelial cells. TIG2 is inhibited in psoriatic lesions and is activated by tazarotene in skin rafts and in epidermis of psoriatic lesions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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