Thermo Fisher Scientific RASA1 Monoclonal Antibody (3D4)
RASA1 단백질을 인식하는 Mouse 모노클로날 항체(클론 3D4)로, WB, ICC/IF, ELISA에 적합합니다. 인간 시료에 반응하며, 비결합형 액상 형태로 제공됩니다. PBS(pH 7.4)에 보존되며, -20°C에서 보관 권장됩니다.
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Thermo Fisher Scientific RASA1 Monoclonal Antibody (3D4)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D4 |
| Immunogen | RASA1 (NP_002881, 948–1047 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AKEPYMEGVN PFIKSNKHRM IMFLDELGNV PELPDTTEHS RTDLSRDLAA LHEICVAHSD ELRTLSNERG AQQHVLKKLL AITELLQQKQ NQYTKTNDVR
Target Information
TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors.
TACC family members (TACC1, TACC2, TACC3) map closely to FGFR1, FGFR2, FGFR3 genes on chromosomes 4, 8, and 10.
Since they are phylogenetically related, TACC and FGFR are proposed to have similar roles in cell growth and differentiation.
TACC1 contains a conserved C-terminal region similar to the Drosophila homolog D-TACC, which is necessary for normal spindle function. Mammalian TACC proteins appear to interact with centrosomes and microtubules in a similar manner.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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