Thermo Fisher Scientific USP15 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:500

Product Specifications

Product Specific Information

Peptide sequence:
GNTDINYIKD DTRHIRFDDR QLRLDERSFL ALDWDPDLKK RYFDENAAED

Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.

Deubiquitination, catalyzed by deubiquitinating enzymes, provides an additional level of ubiquitin regulation. These enzymes fall into four distinct families:

1. Ubiquitin C-terminal hydrolases
2. Ubiquitin-specific processing proteases (USPs)
3. OTU-domain ubiquitin-aldehyde-binding proteins
4. Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these, USPs are the most widespread deubiquitinating enzymes across evolution. They release ubiquitin from conjugated proteins and possess conserved catalytic domains with Cys and His boxes, along with variable N-terminal or C-terminal extensions that contribute to substrate recognition, localization, and protein interactions.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.