Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
Mouse Synaptotagmin 1을 인식하는 Rabbit Polyclonal Antibody로, WB에 1:500–1:2,000 희석 사용 가능. 보존제 무첨가이며, 단백질 A 및 항원 친화 크로마토그래피로 정제됨. 신경 전달 및 시냅스 소포 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the center region of Mouse Synaptotagmin 1 (SYT1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788752 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.
This antibody specifically recognizes Mouse Synaptotagmin 1 (SYT1).
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the CNS and acts as a Ca²⁺ sensor regulating exocytosis and neurotransmitter release.
It mediates Ca²⁺-dependent binding of SNAP25 for membrane fusion triggering. Specific residues in the C2B domain influence endocytic rate and vesicle size.
Synaptotagmin 1 binds acidic phospholipids requiring both an acidic head group and diacyl backbone, and interacts with receptors for activated protein kinase C in a Ca²⁺-dependent manner.
It also binds neurexins, syntaxin, and AP2 in a Ca²⁺-independent manner.
Dysfunction of Synaptotagmin 1 is associated with food-borne and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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