Thermo Fisher Scientific KSR2 Polyclonal Antibody
Thermo Fisher Scientific의 KSR2 Polyclonal Antibody는 인간 및 생쥐 시료에서 KSR2 단백질을 검출하는 토끼 유래 다클론 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 고순도 친화 크로마토그래피 정제 제품으로 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KSR2 (Accession Q6VAB6), corresponding to amino acid residues K674–L724 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850630 |
Product Specific Information
Antibody detects endogenous levels of total KSR2.
Target Information
KSR2 (Kinase Suppressor of Ras 2) serine/threonine kinase specifically regulates the activity of MEKK3 and COT, but not other members of the MAP3K family.
KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK phosphorylation by a separate catalytic Raf molecule in trans.
It blocks MAP3K8 kinase activity and MAP3K8-mediated signaling, acting as a negative regulator of MAP3K3-mediated activation of ERK, JNK, and NF-kappa-B pathways, thereby inhibiting MAP3K3-mediated interleukin-8 production.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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