Thermo Fisher Scientific DOK6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total DOK6.

Target Information

DOK-6 (Docking protein 6) is a member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. It is highly expressed in the developing central nervous system and co-expressed with Ret in multiple locations including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of developing kidneys.

Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Ligand activation of Ret results in phosphorylation of tyrosine residue(s) within the unique C terminus of Dok-6 through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway.

Reference:
Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem. 2004 Oct 1;279(40):42072–81.

Also known as: DOK6, HsT3226, MGC20785, IRS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.