Thermo Fisher Scientific DOK6 Polyclonal Antibody
DOK6 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot과 Immunocytochemistry에 사용 가능하며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DOK6 (Accession Q6PKX4), corresponding to amino acid residues E110–T160. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850629 |
Product Specific Information
Antibody detects endogenous levels of total DOK6.
Target Information
DOK-6 (Docking protein 6) is a member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. It is highly expressed in the developing central nervous system and co-expressed with Ret in multiple locations including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of developing kidneys.
Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Ligand activation of Ret results in phosphorylation of tyrosine residue(s) within the unique C terminus of Dok-6 through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway.
Reference:
Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem. 2004 Oct 1;279(40):42072–81.
Also known as: DOK6, HsT3226, MGC20785, IRS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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