Thermo Fisher Scientific eIF3A/eIF3S10 Polyclonal Antibody
Rabbit polyclonal antibody targeting eIF3A/eIF3S10 for WB and IP applications. Recognizes human eIF3A residues 1–50. Predicted cross-reactivity with rat, zebrafish, and X. tropicalis. Supplied as 1 mg/mL liquid, stored at 4°C, shipped on wet ice.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human translation initiation factor 3 subunit A (eukaryotic translation initiation factor 3, subunit 10) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Zebrafish, and X. tropicalis
Target Information
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773).
The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).
It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition, and is required for disassembly and recycling of post-termination ribosomal complexes.
The eIF-3 complex prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation and specifically targets translation of mRNAs involved in cell proliferation, differentiation, and apoptosis.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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